AirDrop - The icon changes from a package with a parachute to a radar when selected.
/via Niels

AirDrop - The icon changes from a package with a parachute to a radar when selected.

/via Niels

Mac App Store - While downloading a new app, the icon transparency changes according to the progress of the download.
/via Florent Gosselin

Mac App Store - While downloading a new app, the icon transparency changes according to the progress of the download.

/via Florent Gosselin

Mac OS X - Pressing Alt ⌥ and clicking the volume icon lets you select input and output device.
/via jage

Mac OS X - Pressing Alt ⌥ and clicking the volume icon lets you select input and output device.

/via jage

OSX - Excellent integration of the MacApp Store into the OS for unknown file types.

/via Pete Wilkinson

OSX - Excellent integration of the MacApp Store into the OS for unknown file types.

/via Pete Wilkinson

Mac App Store - The progress bar of installing an app from the Mac App Store changes its dimension separate from the icon, when magnified in the dock.

Mac App Store - The progress bar of installing an app from the Mac App Store changes its dimension separate from the icon, when magnified in the dock.

Twitter OS X - Replaces time of the tweet with actions on mouse over.
/via Oldstrech

Twitter OS X - Replaces time of the tweet with actions on mouse over.

/via Oldstrech

Skype 5.0 for Mac - Displays an arrow next to a person’s mood message. When clicking on the arrow, all links will be opened at the same time.
/via Guido

Skype 5.0 for Mac - Displays an arrow next to a person’s mood message. When clicking on the arrow, all links will be opened at the same time.

/via Guido

Twitter for mac - After typing the first few letters of a word, pressing the ESC key will show a list of words that starts with those letters.
Edit: This is a native feature of OSX and works in some other apps as well. 
/via isseykun

Twitter for mac - After typing the first few letters of a word, pressing the ESC key will show a list of words that starts with those letters.

Edit: This is a native feature of OSX and works in some other apps as well. 

/via isseykun

Mac OS X - When searching in the help menu of an app, the menu relevant to the result is pulled down with a blue moving arrow pointing at the menu item. 
/via Stephen Litt Belch

Mac OS X - When searching in the help menu of an app, the menu relevant to the result is pulled down with a blue moving arrow pointing at the menu item. 

/via Stephen Litt Belch

Mac OS X - When doing a calculation in Spotlight, Cmd+C copies the result without having to select it.
/via ELZR

Mac OS X - When doing a calculation in Spotlight, Cmd+C copies the result without having to select it.

/via ELZR